For instance, it has been reported that THP-1 cells and the CD34 + (KG-1) leukaemia cell line incubated with varying concentrations of rhGM-CSF and rhIL-4 for 5 days showed upregulated levels of CD11c, CD80 and CD86 and of the cell-surface receptors CD40, CD209 (DC-SIGN) but failed to express CD83 [64]. The gene discussed is ITGAX; the disease is leukemia.