In fact, circulating cell‐free miRNAs can be detected in EVs or in a vesicle‐free form associated with high‐density lipoproteins or Ago2 protein and there is not a consensus on the relative abundance of miRNAs from these different sources31, 32, 33; however, it has been suggested that those enclosed in EVs may better reflect the presence of the tumor and therefore may serve as more specific disease biomarkers and possibly, therapeutic targets; in fact, increased abundance OSCC‐derived EVs have been reported compared to healthy controls34 suggesting that they may be indeed tumor‐related.35 Here, AGO2 is linked to neoplasm.