Besides, the western blotting results of Rab5 and Rab7 in tumor tissue were decreased, it implied that the hydrolases within lysosomes from endosomes were reduced and the proper function of lysosome was hindered (Figure S5A); however, Dcf1 significantly increased the expression of EEA1, Rab5, and Rab7 (Figure S5B), suggesting that the sufficient supply of hydrolases to lysosomes from endosomes. This evidence concerns the gene TMEM59 and neoplasm.