Particularly, GSEA analysis showed a reduced expression of terms associated with neurodegenerative diseases in SH‐SY5Y‐SNCA and, together with g:Profiler and EnrichR, allowed the identification of a strong enrichment for SNCA‐AS1 and SNCA in pathways concerning synapses and aging as terms involved in this process were amongst the top enriched. Here, SNCA is linked to neurodegenerative disease.