Although there was no statistically significant difference in survival between WT and LXRα/β-KO mice (33% vs 20%) in the absence of α-GalCer treatment when monitored for 70 days (Fig. 4a), the tumor number in the liver of LXRα/β-KO mice was much higher than that in WT mice at 28-day time point (Fig. 4b). This evidence concerns the gene NR1H3 and neoplasm.