WDR45 and neurodegeneration with brain iron accumulation 5: De novo heterozygous mutations in WDR45 have recently been shown to cause β-propeller protein-associated neurodegeneration (BPAN), also known as static encephalopathy of childhood with neurodegeneration in adulthood (SENDA)4, which is a subtype of neurodegeneration with brain iron accumulation (NBIA)5,6.