Moreover, since the growth of NSCLC-derived H1975 cells used in this study is known to depend on the EGFR, growth suppression by AP-1 depletion both in vitro and in vivo (Fig. 8A, B) would provide strong evidence that the effect was mediated by the EGFR depletion. This evidence concerns the gene EGFR and non-small cell lung carcinoma.