Together with recent findings that the depletion of GGA2 suppresses cell proliferation in ARPE-19 [15], and two NSCLC-derived cancer cell lines, PC9 and H1975 [16], it is most likely that both AP-1 and GGA2 have a fundamental influence on cell growth by sustaining the expression of EGFR. The gene discussed is GGA2; the disease is non-small cell lung carcinoma.