To explore the molecular mechanisms that explain cell-specific effects of COVID-19-risk variants in the OAS1 loci, we performed (assay for transposase-accessible chromatin) ATAC-seq analysis of the 13 DICE immune cell types and two activation conditions, and also generated H3K27ac ChIP-seq as well as HiChIP-based chromatin-interaction maps in NCM (see “Methods”). Here, OAS1 is linked to COVID-19.