Increased baseline ADCYAP1 CpG1&2 methylation was a significant predictor of increased PTSD scores at baseline (ß = 5.34, p < 0.001) and decreased PTSD scores at 6-months (ß = −3.52, p = 0.004) post-rape, but the associations were no longer significant when covariates were added to the model. This evidence concerns the gene ADCYAP1 and post-traumatic stress disorder.