As to the association between WNT signaling and CXCR2, it is known that CXCR2 may participate in regulating the lineage commitment of human pluripotent stem cells by activating the β-catenin pathway [35]; however, the mechanism by which CXCR2 regulates NED of PCa via WNT signaling is not clear. Here, CXCR2 is linked to posterior cortical atrophy.