CXCL8 and posterior cortical atrophy: Taken together, we demonstrated that inhibiting AR activities increased TCF7L1 expression, and induction of TCF7L1 through upregulation of WNT4 relieved activation of the oncogenic roles of IL-8 and CXCR2, subsequently leading to the development of malignant progression and the NED of PCa (Fig. 6K).