We further validated TCF7L1 expression with gene signatures reflecting IL-8/CXCR2 signaling components in TCGA PCa dataset and found that tissues expressing high levels of TCF7L1 were robustly associated with a gene signature of upregulated IL-8/CXCR2 responsiveness (PID, Fig. 1H). The gene discussed is CXCR2; the disease is posterior cortical atrophy.