The IL-8/CXCR2/WNT feedback loop was also observed in the development of chemoresistance and metastasis in estrogen receptor (ER)-positive breast cancer, in which WNT signaling is specifically mediated by WNT3A coupled with SNAI1/nuclear factor (NF)-κB signaling activation [60]. The gene discussed is CXCL8; the disease is breast carcinoma.