TCF7L1 and posterior cortical atrophy: Furthermore, TCF7L1 upregulation was positively associated with the gene signature of neural development (gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG)) and negatively associated with the gene signature of the androgen response (GO, pathway interaction database (PID), Wang [39], and Nelson [40]) as confirmed by a GSEA from TCGA PCa database (Fig. 1C), suggesting that TCF7L1 upregulation after ADT is involved in NED progression.