Results showed that tumors from PC3 cells with TCF7L1-KD had decreased TCF7L1, IL-8, CXCR2, and NE marker expressions compared to NC-expressing cells, but there was no significant difference in cell proliferation markers (Fig. 6I, J), confirming that TCF7L1 is an important factor that induces IL-8/CXCR2-associated NED in PCa cells. Here, CXCR2 is linked to posterior cortical atrophy.