Our data confirmed that WNT4 gene silencing in MDV3100-resistant C4-2 and CSS-treated LNCaP cells reduced expressions of TCF7L1 and NE markers, which provides support for the link between endogenous WNT4 and TCF7L1 expressions in PCa cells under AR deprivation. The gene discussed is TCF7L1; the disease is posterior cortical atrophy.