TCF7L1 and prostate adenocarcinoma: We found that AR-suppressed PC3 cells, the NE-like NE-1-8 cell line [45] (LNCaP cells with long-term androgen withdrawal), and an SCPC-like LASCPC01 cell line [13] exhibited higher expressions of TCF7L1 and NE markers and lower expressions of androgen-responsive genes than did the AR-positive LNCaP and C4-2 prostate adenocarcinoma cell lines (Fig. 4A).