To explore the influence of de-core fucosylation on the development of cervical cancer in vivo, we further injected the Fut8+/+ and Fut8−/− SiHa cells into athymic female nude mice and found that the tumor volume and weight in the Fut8−/− SiHa-injected nude mice were significantly higher than that in the Fut8+/+ SiHa-injected nude mice (Fig. 2D, ***p < 0.001). Here, FUT8 is linked to neoplasm.