In contrast, another clinically tested formulation of IL-15 in association with IL-15Rα fused to the Fc domain of immunoglobulin G (ALT-803) showed more prolonged cytokine serum levels and appeared to be better tolerated.38 39 ALT-803 has also been tested as an intravenous infusion and SC injection in patients with advanced solid tumors38 or with relapsed hematologic malignancy following allogeneic hematopoietic stem cell transplantation.39 The gene discussed is GPT; the disease is hematologic disorder.