Analysis of cytokine secretion by mouse BMDMs at 6 and 24 h following treatment with P. aeruginosa LPS found no significant differences in release of several key inflammatory cytokines with the exception of TNF-α, secretion of which by CF macrophages was significantly reduced compared to wild-type (WT) (Fig. 1A). The gene discussed is TNF; the disease is cystic fibrosis.