Expression of proinflammatory Il1β, as measured by qRT-PCR, remained highly upregulated after 24 stimulation with LPS compared to untreated controls but there was no significant difference in the magnitude of this upregulation between CF and WT BMDMs, however, expression of the human orthologue was significantly elevated in patient MDMs at the same time point relative to non-CF controls (Fig. 1C). The gene discussed is IL1B; the disease is cystic fibrosis.