For example, disruption of the CARMA1–BCL10–MALT1 signalosome complex or targeting Nrp1 or Helios or ligation of GITR in Treg cells has been shown to destabilize TIL Treg cells and effectively control tumor without peripheral autoimmune effects reported [19, 21, 47–49]. The gene discussed is CARD11; the disease is neoplasm.