Reactome analysis of different AD groups compared to non-Tg mice showed enrichment of cytokine signaling in immune system with higher induction in APP/PS1/Aβ-Th17 mice, while Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) analysis showed enrichment of networks such as TLR signaling pathway; regulation of TNFR1 signaling, T cell chemotaxis; CC chemokine receptor 5, Toll/IL1 receptor homology (TIR) domain; and IL1-mediated signaling pathways with higher enrichment in APP/PS1/Aβ-Th1 mice compared to untreated APP/PS1 mice. The gene discussed is PSEN1; the disease is Alzheimer disease.