PNPLA3 and chronic kidney disease: These factors were entered into a multivariate analysis, which identified three noninvasive factors that significantly and independently influenced the incidence of CVDs: (1) PNPLA3 genotype (CC type; HR 3.66, 95% CI = 1.63–8.35; P = 0.002), (2) CKD (Presence; HR 3.62, 95% CI = 1.18–11.2; P = 0.025), and (3) FIB-4 index (≥ 2.67; HR 2.73, 95% CI = 1.21–6.14; P = 0.016) as shown in Table 3.