ACE and Alzheimer disease: Migdalov et al. [27] demonstrated that captopril can be used to lower blood pressure by inhibiting ACE. Studies have shown that through the changes in fasting urea and creatinine over one year of dementia caused by Alzheimer’s disease (AD), the use of angiotensin converting enzyme inhibitors has found to be effective for carriers of rs1800764 CT/rs4291 AA.