SMAD2 and Familial prostate cancer: It is found that EMT promotes the activation of Hippo downstream nuclear effector YAP1 and TAZ [35], and ZEB1 can activate YAP1 by inhibiting its repressor miR-375 in prostate cancer [1], while YAP/TAZ activation can also induce EMT [36–38], either by controlling Smad2/3/4 nuclear accumulation and regulating downstream targets Snail, Slug, and Twist1 expression [39] or by inducing expression of ZEB1/2 [40, 41].