A molluscum or mucocutaneous HSV infection of a DOCK8-deficient patient will be assessed differently than in a patient with CVID, and a severe pneumococcal pneumonia of a hypogammaglobulinemic patient will be treated differently from an EBV-linked systemic lymphoproliferative and inflammatory response syndrome in CD27 deficiency, although all of them will be scored as 3° or 4° infection (range 0–4°) depending on treatment response, reversibility, and whether the event was life-threatening. This evidence concerns the gene CD27 and common variable immunodeficiency.