On the other hand, the patterns for CVID, NFKB1, and NFKB2 deficiency resemble each other closely (Fig. 3B), possibly reflecting a large proportion of undetected NFKB1 and NFKB2 deficiencies among CVID cohorts, as do the patterns for the receptor-ligand pair CD27 and CD70 deficiencies (Fig. 3C). This evidence concerns the gene CD27 and common variable immunodeficiency.