LKB1 is a tumor suppressor gene encodes a serine threonine kinase with a stability role in the regulation of cellular metabolism and energy homeostasis.[10] Several studies showed that LKB1 served as a powerful biomarker of tumor functional status could guide clinical trials and patient prognosis assessment.[11] No meta-analysis has been mentioned on LKB1 and its effect on the clinicopathological parameters and prognosis of lung cancer. This evidence concerns the gene MARK2 and neoplasm.