There is usually an upsurge in the Ki-67 labeling index in diffuse gliomas with malignancy grade of about <5% in low-grade diffuse gliomas, 5% to 10% in anaplastic gliomas, as well as >10% in glioblastomas.[15,18] Initial, the WHO grade I encompass pilocytic astrocytoma's, grade II were low-grade astrocytoma's (astrocytoma grade I and II), grade III were anaplastic astrocytoma's (astrocytoma grade III) while grade IV were glioblastoma multiform (astrocytoma grade IV).[19]. The gene discussed is MKI67; the disease is glioblastoma.