EFEMP1 and hemorrhoid: Fibulin-3 can form and stabilize basement membrane, elastic fibers, and loose connective tissue.[17] Fibulin-5 not only acts on the synthesis of elastic fibers, but also inhibits neovascularisation.[18] This study will take the classic RBL as the control, through a prospective randomized controlled experiment to explore the efficacy and safety of Shaobei injection in the treatment of grade II–III hemorrhoids, evaluate its effect on the expression of fibulin-3 and fibulin-5 in fibulin protein family, and explore the potential mechanism of Shaobei injection in the treatment of hemorrhoids.