EFEMP1 and hemorrhoid: This study will take the classic minimally invasive surgery scheme and RBL as the control group to explore the efficacy and safety of Shaobei injection in the treatment of grade II–III hemorrhoids, and we also pay attention to the expression of fibulin-3 and fibulin-5 in fibulin protein family, in order to explore the potential mechanism of Shaobei injection in the treatment of hemorrhoids.