APE1 rs1130409 polymorphism T to G, in the biological significance, APE1 codon T to G polymorphism is associated with the delay of lymphocyte mitosis in healthy subjects, suggesting a higher sensitivity to ionizing radiation.[39] And some authors describe the relationship between allele G and prostate cancer.[40] Some studies have analyzed this transition and support this polymorphism as a low penetrance risk factor for cancer development.[41]. This evidence concerns the gene APEX1 and Familial prostate cancer.