Some studies reported that this polymorphism may increase the risk of PCa, but other studies did not.[16–22] Therefore, we systematically reviewed the available literature and performed a meta-analysis to evaluate the the relationship between APE1 rs1760944 and rs1130409 gene polymorphisms and PCa risk, which may provide valuable insights for the risk assessment of PCa. This evidence concerns the gene APEX1 and posterior cortical atrophy.