s139 phosphorylated H2A.X was shown to be associated with lung, breast, lung, ovarian, and colorectal cancer.[21] Phosphorylated histone H2AX now is considered to be a biomarker of precancerous liver cancer.[22] Although there have many studies on the relationship between histone variants and covalent modifications of the canonical H2A family and cancer in recent years, few studies have been conducted on its relationship with cancer due to the small variation of the canonical H2A sequence, and the functional significance of the H2A is still unclear at present. This evidence concerns the gene H2AX and liver cancer.