H2AC25 and asthma: We found that the higher expression of HIST3H2A was positively correlated with the JAK-STAT signaling pathway (Fig. 4A), whereas intestinal immune network for IgA production (Fig. 4B), asthma (Fig. 4C), chemokine signaling pathway (Fig. 4D), glycine serine, and threonine metabolism (Fig. 4E) were enriched in the HIST3H2A low expression phenotype, suggesting that pathway may be involved in the function of HIST3H2A.