The SLC12 family of proteins includes SLC12A8 and SLC12A9, which encode proteins for which no function has yet been ascribed.[28] Due to the limited research on HIST3H2A in pancreatic cancer patients, So the interaction between HIST3HI2A and these genes (SLC12A8 and SLC12A9) needs further experimental study. The gene discussed is H2AC25; the disease is familial pancreatic carcinoma.