DMD and Duchenne muscular dystrophy: Importantly, groups of DMD+/− carrier sows can be estrus-cycle synchronized and inseminated with semen from the same boar to reliably produce large cohorts of DMDY/− pigs and WT littermate controls for studies with statistically relevant group sizes (see Tables S6 and S7 for group size calculations regarding improvements of the cardiac and behavioral phenotypes), allowing for fast and effective testing of new treatment options in a large-animal model for DMD with high clinical resemblance to the human phenotype, but accelerated disease progression.