In DMD+/− pigs, a wide variation in serum CK activities was observed, ranging from levels within the cluster of WT pigs to highly elevated levels as in DMDY/− pigs, similar to human dystrophinopathy carriers (Ishizaki et al., 2018) (Fig. 1G). This evidence concerns the gene DMD and neuromuscular disease caused by qualitative or quantitative defects of dystrophin.