In this respect it is notable that two of the ALS cases are also heterozygous for I114T (previously reported as I113T) SOD1 and L17P FIG4 variant alleles that have previously been linked to ALS or recessive Charcot-Marie-Tooth disease type 4 J (CMT4J). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.