While removal of SARM1 does not alleviate motor neuron degeneration in a SOD1 model of ALS (Peters et al., 2018), this could be explained by the finding that TDP-43 aggregation is usually not seen in ALS linked to SOD1 or FUS mutations (Mackenzie et al., 2007; Maekawa et al., 2009; McAlary et al., 2019). Here, SOD1 is linked to amyotrophic lateral sclerosis.