SARM1 and amyotrophic lateral sclerosis: While no firm association between SARM1 variation and human disease has yet been established, genome wide association studies (GWAS) have linked the SARM1 chromosomal locus, including an intragenic SNP, to sporadic ALS (Fogh et al., 2014; van Rheenen et al., 2016), although whether SARM1 is the causative gene is not known.