SARM1 and amyotrophic lateral sclerosis: Here, we have identified a number of rare alleles specific to ALS patients in Project MinE initiative data freeze 1 (Project MinE ALS Sequencing Consortium, 2018; van der Spek et al., 2019) and the Answer ALS project (Rothstein et al., 2020) encoding missense substitutions and in-frame microdeletions in the auto-inhibitory ARM domain of SARM1 that confer substantial pro-degenerative NADase gain-of-function (GoF).