SARM1 and amyotrophic lateral sclerosis: P332Q SARM1, a more common variant equally abundant in ALS patients and controls, appears much more inducible than WT SARM1 (Figure 3—figure supplement 2C), but this largely reflects its substantially lower constitutive activity with its NMN-activated rate being only marginally higher than that of WT SARM1 (Figure 3C and Figure 3—figure supplement 2A).