Specifically, STMN2 depletion increases the vulnerability of ALS patient iPSC-derived neurons (Klim et al., 2019; Melamed et al., 2019), and a non-coding STMN2 variant that influences gene expression has recently also been associated with increased risk of sporadic disease (Theunissen et al., 2021). The gene discussed is STMN2; the disease is amyotrophic lateral sclerosis.