SARM1 and Leber congenital amaurosis: However, recent studies do suggest direct involvement of SARM1 in neuronal cell death in some situations, including photoreceptor loss in models of retinal degeneration and Leber congenital amaurosis (LCA) (Ozaki et al., 2020; Sasaki et al., 2020) and as a result of Vacor neurotoxicity when specifically applied to cell bodies (Loreto et al., 2021).