CD274 and cancer: In various cancer types, programmed cell death-ligand 1 (PD-L1; encoded by the CD274 gene) and programmed cell death 1 ligand 2 (PD-L2, CD273, encoded by the PDCD1LG2) suppressed T cell activation and facilitated immune evasion by binding to PD-1 on lymphocytes [57,58].