In conclusion, the present study has revealed that PANX1 overexpression is correlated with poor prognosis and increased immune infiltration of CAF, macrophage, neutrophil, and myeloid dendritic cells in multiple cancers, particularly PAAD Furthermore, PANX1 expression is closely associated with immunomodulators such as CD274, IL10, CD276, CD80, and IL2RA. Here, PANX1 is linked to pancreatic adenocarcinoma.