CD274 and neoplasm: In vivo experiments demonstrated that the combination of PTT with systemic antitumor immune responses triggered by efficient PD‐L1 silencing could not only eliminate 4T1 orthotopic tumor but also inhibit the growth of distant tumors, metastasis, and recurrence due to the generation of immune memory (Figure 8e–g).[82] Therefore, ATP‐responsive nanomedicine has become a research hotspot to enhance the antitumor effect of immunotherapy, which may attract more attention in the near future.