In addition, the extracellular lactic acid program reduced the TAM phenotype from M2 the type to M1 type, restored the activity of CD8+ T cells, and eliminated the immunosuppressive TME.[54] Li and co‐workers fabricated an amphiphilic triblock copolymer PS3D1@DMXAA, which could release the loaded 7‐ethyl‐10‐hydroxycamptothecin (SN38) from the polymer under a high level of GSH in the tumor tissue, which induced tumor cell death and enhanced tumor immunogenicity.[55] Tang et al. The gene discussed is CD8A; the disease is neoplasm.