Under irradiation by a laser, the nanomedicine stimulated adaptive antitumor immunity by generating singlet oxygen and promoting the uptake of tumor‐derived antigens by an APC reaction, leading to the suppression of tumor metastasis (Figure 2b).[28] In addition, Cai and co‐workers developed a pH‐responsive nanocarrier loaded with PS PPa and PD‐L1–blockade siRNA for the synergistic integration of PDT and immunotherapy (Figure 2c). Here, CD274 is linked to neoplasm.