MTOR and neoplasm: Meanwhile, circ‐ERBIN can also activate hypoxia‐inducible factor‐1α (HIF‐1α) to improve tumor angiogenesis, indicating that circ‐ERBIN coregulates the translation of 4E binding protein 1 (4EBP‐1) to increase the protein level of HIF‐1α and promote the phosphorylation state through mTOR signaling at the non‐cap‐dependent protein level.