However, it is worth thinking about whether the phosphatidylinositol 3‐kinase/Akt pathway regulates hsa‐circ‐002144 for tumor intervention; furthermore, how hsa‐circ‐002144 regulates E‐cadherin and N‐cadherin and participates in the epithelial–mesenchymal transition of CRC needs to be verified.25 This evidence concerns the gene AKT1 and colorectal carcinoma.