It is noteworthy that ERBIN is involved in a variety of malignant tumors, including CRC, but linear ERBIN is easily degraded under the action of actinomycin D. Among them, ERBIN maintains cell polarity, indicating that circ‐ERBIN and ERBIN have a common trend in CRC tumorigenesis and protein translation; however, the regulatory mechanism of circ‐ERBIN and linear ERBIN is not yet clear. This evidence concerns the gene ERBIN and cancer.