Approximately 40% of MS patients also show oligoclonal IgM bands (OCMB) in CSF (Villar et al., 2010), which has been reported as being a risk factor for poor prognosis both clinically and imaging (Perini et al., 2006; Pfuhl et al., 2019; Thangarajh et al., 2008; Villar et al., 2003). The gene discussed is CD40LG; the disease is myeloid sarcoma.