We detected 323 and 152 differentially expressed genes (DEGs) in female and male APP/PS1 mice, respectively, as compared to WT (with an overlap of 92 DEGs; FDR <0.1), indicating that there is a greater effect of AD pathology on gene expression in female mice at this age (Figure 6a,b and Figure S1a). This evidence concerns the gene APP and Alzheimer disease.