Based on the analysis of promoter hypermethylation in 45 candidate genes in 10 neuroblastoma cell lines and 10 selected genes in 118 primary neuroblastomas through methylation-specific PCR, Alaminos et al. reported that the CpG island hypermethylation portrait showed distinct patterns for MYCN-amplified versus nonamplified tumors (69). The gene discussed is MYCN; the disease is neuroblastoma.