In diabetic mouse, DM compromises the BM niches by down-regulating adhesion molecule VCAM1, chemokine SDF-1, pro-angiogenic cytokine VEGF, peptidase DPP-4 and et al. The disturbed stem cells niche leads to stem cells dysfunctions, thereby, impairing the mobilization of HSPCs (Orlandi et al., 2010). This evidence concerns the gene CXCL12 and diabetes mellitus.