Moreover, miR-146a-5p is known to attenuate liver fibrosis through the regulation of fibrosis-associated pathways, such as TGF-β/SMAD (He et al., 2012; Zou et al., 2017, 2019), Wnt/β-catenin (Du et al., 2015), LPS/TLR4/NF-κB (Chen et al., 2016; Chen Y. et al., 2018; Zou et al., 2019; Niu et al., 2020), and PTPRA-SRC (Yuan et al., 2019). Here, TLR4 is linked to Hepatic fibrosis.