It has been reported that several proteins, such as NRF2, DAZAP1, metallothionein-1G (MT-1G), Branched-chain amino acid aminotransferase 2 (BCAT2), and CDGSH iron-sulfur domain 1 (CISD1), inhibit ferroptosis in HCC cells through different ways. This evidence concerns the gene NFE2L2 and hepatocellular carcinoma.