However, IFNγ produced by effector CD8+ T cells downregulates SLC7A11 and SLC3A2 by reducing the release of cysteine and GSH from CAFs, thereby inhibiting cystine uptake in cancer cells, resulting in the induction of tumor lipid peroxidation and ferroptotic cell death (Wang et al., 2016). The gene discussed is SLC7A11; the disease is cancer.