KRAS and cancer: During Kras-driven PDAC in mice, ferroptotic cancer cells promote the release of damage-associated molecular patterns (DAMPs) such as 8-hydroxy-2ʹ-deoxyguanosine (8-OHG) and KRAS-G12D protein, leading to macrophage polarization and subsequent pancreatic tumor growth (Dai et al., 2020a; Dai et al., 2020b).