Ferroptotic cancer cells can release and activate distinct signals including DAMPs (e.g., HMGB1, KRAS-G12D, and 8-OHG) or oxidized lipid mediators (e.g., 4HNE, oxPLs, LTB4, LTC4, LTD4, and PGE2) that may modulate inflammatory and anti-tumor immunity. Here, HMGB1 is linked to cancer.