HMGB1 and cancer: On the other hand, recent evidence indicated that ferroptotic cancer cells could release signal molecules, including oxidized lipid mediators, eicosanoids, and high mobility group box1 (HMGB1) (Friedmann Angeli et al., 2014; Kagan et al., 2017; Wen et al., 2019), into the ECM to modulate the anti-cancer immunity.