Sun et al. revealed that activation of the p62-Keap1-NRF2 pathway prevents HCC cells from ferroptosis, and the Ras/Raf/MEK pathway is an important target for ferroptosis in the treatment of HCC (Sun et al., 2016b; Nie et al., 2018). The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.