Accumulating evidence has shown genomic alterations and abnormal expression of APE2 expression in multiple cancer tissues, including pancreatic cancer and multiple myeloma (MM), and APE2 is proposed to function as an oncogene in liver cancer (Kumar et al., 2018; Jensen et al., 2020; Zheng et al., 2020). Here, APEX2 is linked to familial pancreatic carcinoma.