SLC2A3 and Hyperglycemia: Animal experiments have demonstrated that the expression of placental GLUT3 responds to streptozotocin (STZ)-induced maternal hyperglycemia (Boileau et al., 1995), which indicates that aberrant expression patterns and/or dysfunction of GLUT3 in the placenta might be involved in disturbances in glucose metabolism and thus in the development of GDM.