Although neither GLUT3 nor HIF-1α expression was altered under hyperglycemic conditions (Figure 3D), the PM-bound GLUT3 level was significantly reduced by hyperglycemia treatment (Figure 3E and Supplementary Figure 2D), and consistent with this finding, glucose uptake was almost entirely eliminated under high-glucose conditions (Figure 3F). Here, HIF1A is linked to Hyperglycemia.