As Figure 1C shown, after the HA-modified MTM entering the tumor tissues, hyaluronidase decomposes hyaluronic acid to release Au 25 Sv 9 to remove thioredoxin reductase in tumor cells, MnO2 catalyzes H2O2 to produce oxygen to improve hypoxia environment, which promoted the killing effect of photodynamic action through light-excited TiO2. The gene discussed is PRDX5; the disease is neoplasm.