It has been reported that T. cruzi–infected humans and mice displayed an enhanced frequency of CD4+ and CD8+ cells within the intracardiac inflammatory infiltrates, with a predominance of CD8+ T cells being correlated with the progression of the cardiac disease (Higuchi M de et al., 1993; Tarleton et al., 1994; Fuenmayor et al., 2005). Here, CD4 is linked to heart disorder.