Aiming to understand more clearly the dynamics of T-cell migratory events that may influence the development of CCM, we evaluated herein the migratory capacity of T cells derived either from healthy or chronic chagasic patients, with or without cardiac involvement, and whether such migratory response is influenced by chemotactic, e.g., CXCL12, TNF-α, or haptotactic molecules such as the ECM protein fibronectin. Here, TNF is linked to cerebral cavernous malformation.