CEACAM5 and neoplasm: Moreover, Table 1 showed that increased ITGB6 serum levels were closely associated with the TNM stage of tumor size (P=0.001), T stage (P=0.050), N stage (P=0.001), TNM stage (P=0.007), neurovascular infiltration (P=0.008) and serum CEA levels (P<0.001).