CYP17A1 and lung carcinoma: In addition, CP450-related genes also play important roles in other cancers: CYP4Z1 is involved in regulating breast cancer progression (41), the CYP17 inhibitor prevents the growth of prostate cancer cells (42), CYP24A1, a proto-oncogene in human lung cancer, has anti-differentiation and anti-proliferative effects in human lung cancer cell lines (43), and CYP1B1 causes apoptosis in neural cancer cells by inducing melatonin (44).