In addition, CP450-related genes also play important roles in other cancers: CYP4Z1 is involved in regulating breast cancer progression (41), the CYP17 inhibitor prevents the growth of prostate cancer cells (42), CYP24A1, a proto-oncogene in human lung cancer, has anti-differentiation and anti-proliferative effects in human lung cancer cell lines (43), and CYP1B1 causes apoptosis in neural cancer cells by inducing melatonin (44). This evidence concerns the gene CYP17A1 and Familial prostate cancer.