Mitochondrial dynamics-associated genes (MTP18, FIS1), mitochondrial protein import-associated genes (TOMM40, TOMM7), mitophagy-associated genes (PINK1) and glucose metabolism-associated genes (FBP1, TPI1 and PCK1) were significantly down-regulated in HCC patients with high GMFB expression (Table 1). The gene discussed is PCK1; the disease is hepatocellular carcinoma.