Among top 100DEGs, some of them with statistical significance of survival analysis, such as Dodecenoyl-CoA isomerase (DCI, p value=4.3e-5 in males), G2/M phase-specific E3 ubiquitin-protein ligase (G2E3, p value=9.5e-6 in males), LSM domain-containing protein 1 (LSMD1, p value=0.0001 in males), Neural precursor cell expressed developmentally down-regulated protein 1 (NEDD1, p value=0.0001 in males) and Ras-related GTP-binding protein C (RRAGC, p value=0.0001 in females) have not been reported in HCC yet. The gene discussed is UBE2E3; the disease is hepatocellular carcinoma.