The second dead signature gene was CEP112, a centrosomal protein involved in cell division, known to play a key role in the maintenance of genomic stability in association with BRCA1 (69) and ZNF568, with the most significant contribution to the dead gene signature with a particular mutation present in 12 dead and 10 alive patients, indicating ZNF568 role in tumor suppression. This evidence concerns the gene BRCA1 and neoplasm.