Transcription factors like NOTCH1 (16%) and KMT2B (16%), UNC13C (14%), another tumor suppressor, ERCC2 (14%) involved in nucleotide excision repair pathway, were recurrently mutated, whereas genes like CDKN2A, MLH1, FGFR1, EGFR, etc. had a less than 10% mutation frequency. The gene discussed is NOTCH1; the disease is neoplasm.