MYC and squamous cell carcinoma: Accumulation of structural variants such as Copy number variation (CNV), Loss of Heterozygosity (LOH) in oncogenes, and tumor suppressors like c-MYC, EGFR, CDKN2A, respectively, have been associated with recurrence of squamous cell carcinomas, and poor prognosis and outcome predictions have been linked to rapid occurrence rates of SCNAs across tumor genomes (4, 14, 15).