In HNSCC, mutations in a known set of tumor suppressors and oncogenes, namely TP53, CCND1, NOTCH1, PIK3CA, MYC, CDKN2A, PTEN, and FBXW7, have been reported, but most of them are not associated with survival (4, 44). Here, CDKN2A is linked to head and neck squamous cell carcinoma.