EGFR and non-small cell lung carcinoma: In conclusion, a pretreatment PET/CT radiomics biomarker for the prediction of the PFS of NSCLC patients with stage IIIC/IV EGFR mutations was established; it has the potential to realize the precise quantitative stratification of progression risk after first-line first and second generation of EGFR-TKI drug therapy and identify EGFR-mutant NSCLC populations sensitive to targeted therapy.