SPAG5, which interacts with centrosomal protein CEP55 resulting in the phosphorylation of AKT at Ser473, promotes hepatocellular carcinoma growth via CEP55-mediated Phosphatidyl inositol -3- hydroxykinase (PI3K)/(protein kinase B) AKT pathway (28). Here, AKT1 is linked to hepatocellular carcinoma.