In the future, long-term studies should be conducted to explore clinical markers for early cardiovascular disease that include increased carotid intima-media thickness, left ventricular mass and pulse wave velocity, flow-mediated dilatation, retinal vascular narrowing, or increased cardiovascular biomarkers (interleukin-6, fibrinogen, and so on) [37–39], which would be useful for the establishment of HBP definition in children and adolescents. Here, IL6 is linked to cardiovascular disorder.