In a transgenic mice model of Alzheimer’s disease (5xFAD), we found a significant decrease in the expression of CD147 in the CA3 region of the hippocampus; in animals of the control group, the dentate gyrus had a lower (compared to other regions of the hippocampus) level of CD147 expression [35]. This evidence concerns the gene BSG and early-onset autosomal dominant Alzheimer disease.