With the combination of COVID-19 and DM, hyperglycemia is persistent, without pronounced variability (MAGE — 1.5±0.6 mmol/L), the levels of C-reactive protein (p=0.028), creatinine (p=0.035), and fibrinogen (p=0.013) are higher, manifestations of hypercoagulability persist longer, including slower normalization of antithrombin III (p=0.012), fibrinogen (p=0.037), and D-dimer (p=0.035). The gene discussed is SERPINC1; the disease is COVID-19.