Some authors describe osteoarthritis as a low-grade local inflammatory process based on the presence in osteoarthritic joints of proinflammatory cytokines (a cohort of interleukins such as IL-1β, IL-6, IL-15, IL-17, IL-18, IL-21, tumor necrosis factor-alpha, and leukemia inhibitory factor) and chemokines that are not carried by systemic circulation [8], possibly including innate immunity mechanisms such as recognition of damage-associated molecular patterns and involvement of complement effectors that can mediate synovial macrophage and mast cell activation [9]. This evidence concerns the gene IL6 and osteoarthritis.