In heart failure following ischemic heart injury, a strong inflammatory response leads to further injury and dysfunction of cardiac contraction and expansion, and the release of cell debris during tissue injury causes conformational changes in NLRP3 inflammasomes, leading to the activation of caspase-1.Clinical treatment of heart failure patients with IL-1 antagonist injection showed increased oxygen consumption, which is expected to be a new direction of heart failure treatment in the future. Here, CASP1 is linked to heart failure.